4.1Concept: the exposure chain from source to effect#
In brief
A pollutant harms health through a chain: source, release, transport in air, water, soil or food, exposure by inhalation, ingestion or skin contact, absorption, and then an…
A pollutant harms health through a chain: source, release, transport in air, water, soil or food, exposure by inhalation, ingestion or skin contact, absorption, and then an effect on a target organ. The size of the effect depends on the dose, the duration of exposure and the vulnerability of the person, which is why toxicology talks about dose-response relationships. Acute exposure is short and intense (the Bhopal gas leak), while chronic exposure is long-term and often low-level (arsenic in drinking water, particulate matter, lead). Children, pregnant women, the elderly and people with existing lung or heart disease are more vulnerable, and children are especially at risk because they breathe more air per unit body weight and their organs are still developing.
Some pollutants are carcinogens (cause cancer), mutagens (cause changes in DNA), teratogens (cause birth defects), endocrine disruptors (interfere with hormones), or neurotoxins (damage the nervous system). The International Agency for Research on Cancer classifies substances in Group 1 when they are carcinogenic to humans, and outdoor air pollution and particulate matter were classified in Group 1 in 2013. Persistent substances (DDT, PCBs, mercury) bioaccumulate in body fat or tissue and biomagnify along the food chain, so top consumers, including humans, carry the highest burdens. Air pollution is generally regarded as the largest single environmental health risk worldwide.